An age-dependent diet-modified effect of the PPARγ Pro12Ala polymorphism in children.

doi:10.1016/j.metabol.2010.04.007

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Article

An age-dependent diet-modified effect of the PPARγ Pro12Ala polymorphism in children.

Metabolism: clinical and experimental - 1 Apr 2011

Dedoussis George V, Manios Yannis, Kourlaba Georgia, Kanoni Stavroula, Lagou Vasiliki, Butler Johannah, Papoutsakis Constantina, Scott Robert A, Yannakoulia Mary, Pitsiladis Yannis P, Hirschhorn Joel N, Lyon Helen N

Abstract excerpt

Variation in the peroxisome proliferator-activated receptor γ gene alters the risk for adiposity in adults, with evidence of interaction with diet. We investigated the age-related association between the Pro12Ala variant (rs1801282) and diet in obesity-related traits in children. The Pro12Ala variant was assayed in 2102 young children aged 1 to 6 years and in 794 periadolescent children aged 10 to 12 years of...

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PMID: 20580778
DOI: 10.1016/j.metabol.2010.04.007

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