Article
A syndrome of insulin resistance resembling leprechaunism in five sibs of consanguineous parents.
Journal of medical genetics - 1 Jun 1993
al-Gazali L I, Khalil M, Devadas K
Abstract excerpt
Leprechaunism is a rare autosomal recessive disorder associated with extreme insulin resistance with paradoxical hypo-glycaemia. It is characterised by prenatal and postnatal growth retardation, reduced subcutaneous tissue, coarse features, acanthosis nigricans, enlarged genitalia, and death in t...
Topics
- Child
- Child, Preschool
- Consanguinity
- Female
- Humans
- Insulin Resistance
- Insulin-Like Growth Factor I
- Lipodystrophy
- Male
- Mutation
- Pedigree
- Receptor, Insulin
- Yemen