Article
Therapeutic monitoring of antidepressants in the era of pharmacogenetics studies.
Therapeutic drug monitoring - 1 Apr 2004
Eap C B, Jaquenoud Sirot E, Baumann P
Abstract excerpt
As for other drugs, there is a large interindividual variability of the plasma concentrations of antidepressants for a given dose. Within the last 2 decades, a very large number of pharmacogenetic studies have made it possible to understand the importance of genetic factors on the disposition of drugs in the organism, many of them at the levels of drug metabolism. Polymorphism of CYP2D6 and of other...
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