Article
Effect of radiation and ibuprofen on normoxic renal carcinoma cells overexpressing hypoxia-inducible factors by loss of von Hippel-Lindau tumor suppressor gene function.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2004
Palayoor Sanjeewani T, Burgos Melissa A, Shoaibi Azadeh, Tofilon Philip J, Coleman C Norman
Abstract excerpt
PURPOSE: Tumor hypoxia is a major limiting factor for radiation therapy. Hypoxia-inducible factors (HIFs) are overexpressed in several human cancers and are considered prognostic markers and potential targets for cancer therapy. The purpose of the present study was to investigate the impact of HIFs on radiosensitivity. EXPERIMENTAL DESIGN: Renal clear cell carcinoma (RCC) cell lines overexpressing HIFs under...
Topics
- Anti-Inflammatory Agents, Non-Steroidal
- Basic Helix-Loop-Helix Transcription Factors
- Blotting, Western
- Carcinoma
- Cell Line
- Cell Survival
- Dose-Response Relationship, Drug
- Dose-Response Relationship, Radiation