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The r131 gene of rat cytomegalovirus encodes a proinflammatory CC chemokine homolog which is essential for the production of infectious virus in the salivary glands.

Virus genes - 1 Aug 2004

Kaptein Suzanne J F, van Cleef Koen W R, Gruijthuijsen Yvonne K, Beuken Erik V H, van Buggenhout Lieve, Beisser Patrick S, Stassen Frank R M, Bruggeman Cathrien A, Vink Cornelis

Abstract excerpt

Rat cytomegalovirus (RCMV) possesses two adjacent genes, r131 and r129, which have the potential to encode CC chemokine homologs. Interestingly, the amino acid sequences encoded by both genes show similarity to the sequence of the murine CMV (MCMV) MCK-2 protein, which is encoded by the m131/129 gene. In order to study the significance of the r131 gene in the pathogenesis of RCMV infection, we generated two...

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PMID: 15215683
DOI: 10.1023/B:VIRU.0000032788.53592.7c

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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