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Article

Overexpression of PDZK1 within the 1q12-q22 amplicon is likely to be associated with drug-resistance phenotype in multiple myeloma.

The American journal of pathology - 1 Jul 2004

Inoue Jun, Otsuki Takemi, Hirasawa Akira, Imoto Issei, Matsuo Yoshinobu, Shimizu Shiroh, Taniwaki Masafumi, Inazawa Johji

Abstract excerpt

We investigated DNA copy number aberrations in 37 cell lines derived from multiple myelomas (MMs) using comparative genomic hybridization, and 11 (29.7%) showed high-level gain indicative of gene amplification at 1q12-q22. A corresponding transcriptional mapping using oligonucleotide arrays extracted three up-regulated genes (IRTA2, PDZK1, and S100A6) within the smallest region of overlapping in amplifications....

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Share to Antineoplastic Agents, Alkylating
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 1

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Share to Drug Resistance, Multiple

Share to Melphalan

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Source

Open in PubMed Open full text

Identifiers

PMID: 15215163
DOI: 10.1016/S0002-9440(10)63276-2
PMCID: PMC1618545

Genes

PDZK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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