A family with haemolytic anaemia and three beta-globins: the deletion in haemoglobin Atlanta-Coventry (beta 75 Leu----Pro, 141 Leu deleted) is not present at the nucleotide level.

doi:10.1111/j.1365-2141.1992.tb08178.x

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Article

A family with haemolytic anaemia and three beta-globins: the deletion in haemoglobin Atlanta-Coventry (beta 75 Leu----Pro, 141 Leu deleted) is not present at the nucleotide level.

British journal of haematology - 1 May 1992

George P M, Myles T, Williamson D, Higuchi R, Symmans W A, Brennan S O

Abstract excerpt

Analyses of haemoglobin from a family with an unstable haemoglobin haemolytic anaemia demonstrated that the affected individuals had three beta-globins, namely, normal (beta A), Atlanta (beta At) with a mutation of beta 75 Leu----Pro, and beta-Atlanta-Coventry (beta At-Co) with mutation of beta 75 Leu----Pro and beta 141 Leu deleted. These were present in the ratio 66:23:11 respectively. The structure of the...

Topics

Anemia, Hemolytic
Base Sequence
Blotting, Southern
Chromosome Deletion
Codon
DNA
Female
Globins
Hemoglobins, Abnormal
Humans
Leucine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Molecular Sequence Data

Mutation

Pedigree

Polymerase Chain Reaction

Proline

RNA, Messenger

Source

Open in PubMed

Identifiers

PMID: 1520631
DOI: 10.1111/j.1365-2141.1992.tb08178.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1520631-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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A family with haemolytic anaemia and three beta-globins: the deletion in haemoglobin Atlanta-Coventry (beta 75 Leu----Pro, 141 Leu deleted) is not present at the nucleotide level.PMID 1520631Read ↗

Beta 141 Leu is not deleted in the unstable haemoglobin Atlanta-Coventry but is replaced by a novel amino acid of mass 129 daltons.Semantic proximity Read ↗

Hemoglobin Birmingham and hemoglobin Galicia: two unstable beta chain variants characterized by small deletions and insertions.Semantic proximity Read ↗

Hb Nancy and Hb Osler: two distinct genetic variants with identical clinical and hemoglobin phenotype.Semantic proximity Read ↗

HAEMOGLOBINOPATHIESSemantic proximity Read ↗

Hemoglobinopathies.Semantic proximity Read ↗

Hb Stara Zagora: a new hyper-unstable hemoglobin causing severe hemolytic anemia.Semantic proximity Read ↗

Hb Jambol: a new hyperunstable hemoglobin causing severe hemolytic anemia.Semantic proximity Read ↗

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