Article
Delta F508 mutation of cystic fibrosis gene is not found in chronic bronchitis with severe obstruction in Japan.
The American review of respiratory disease - 1 Sept 1992
Akai S, Okayama H, Shimura S, Tanno Y, Sasaki H, Takishima T
Abstract excerpt
Diffuse panbronchiolitis (DPB) in Japan is a chronic bronchitis observed in nonsmoking adults, with severe obstruction and poor prognosis. DPB shares pathologic and clinical characteristics with mild adult cystic fibrosis (CF), except that CF is frequent in whites (Europeans and Americans of European descent) but not in Japanese. Recently, the cystic fibrosis transmembrane conductance regulator (CFTR) gene was...
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