Article
Common CFTR mutations are not likely to predispose to chronic bronchitis in northern Germany.
Human genetics - 1 Feb 1995
Artlich A, Boysen A, Bunge S, Entzian P, Schlaak M, Schwinger E
Abstract excerpt
The frequency of six common mutations in the cystic fibrosis transmembrane conductance regulator gene was studied in 100 patients hospitalized with chronic bronchitis. Only one patient with chronic bronchitis and diffuse bronchiectasis was heterozygous for the common delta F508 mutation. R553X, G542X, G551D, N1303K and 621 + 1G-->T were not detected. This result is not significantly different from the frequency...
Topics
- Aged
- Base Sequence
- Bronchitis
- Chronic Disease
- Cystic Fibrosis Transmembrane Conductance Regulator
- DNA
- Female
- Germany
- Humans
- Male
- Membrane Proteins
- Middle Aged