Article
CCR5 promoter polymorphism influences the interferon response of patients with chronic hepatitis C in Japan.
Intervirology - 1 Jan 2004
Konishi Ichiro, Horiike Norio, Hiasa Yoichi, Michitaka Kojiro, Onji Morikazu
Abstract excerpt
OBJECTIVE: Chemokines and chemokine receptors play important roles in the pathogenesis of chronic hepatitis C. Here, we explore the influence of genetic polymorphisms of chemokine and chemokine receptors such as regulated upon activation and T cell secreted (RANTES), CC chemokine receptor 5 (CCR5) and CCR2 on the outcome of interferon (IFN) monotherapy. METHODS: In a cohort of 105 patients with chronic hepatitis...
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