Article
Novel chimeric spermidine synthase-saccharopine dehydrogenase gene (SPE3-LYS9) in the human pathogen Cryptococcus neoformans.
Eukaryotic cell - 1 Jun 2004
Kingsbury Joanne M, Yang Zhonghui, Ganous Tonya M, Cox Gary M, McCusker John H
Abstract excerpt
The Cryptococcus neoformans LYS9 gene (encoding saccharopine dehydrogenase) was cloned and found to be part of an evolutionarily conserved chimera with SPE3 (encoding spermidine synthase). spe3-lys9, spe3-LYS9, and SPE3-lys9 mutants were constructed, and these were auxotrophic for lysine and spermidine, spermidine, and lysine, respectively. Thus, SPE3-LYS9 encodes functional spermidine synthase and saccharopine...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.