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Article

Association of the polycystic ovary syndrome with genomic variants related to insulin resistance, type 2 diabetes mellitus, and obesity.

The Journal of clinical endocrinology and metabolism - 1 Jun 2004

San Millán José L, Cortón Marta, Villuendas Gemma, Sancho José, Peral Belén, Escobar-Morreale Héctor F

Abstract excerpt

We have evaluated the possible association of polycystic ovary syndrome (PCOS) with 15 genomic variants previously described to influence insulin resistance, obesity, and/or type 2 diabetes mellitus. Seventy-two PCOS patients and 42 healthy controls were genotyped for 15 variants in the genes encoding for paraoxonase (three variants), plasma cell differentiation antigen glycoprotein, human sorbin and SH3 domain...

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Source

Identifiers

PMID: 15181035
DOI: 10.1210/jc.2003-031252

Genes

IGF2
IGF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Association of the polycystic ovary syndrome with genomic variants related to insulin resistance, type 2 diabetes mellitus, and obesity.PMID 15181035Read ↗

[Combined analyses of paraoxonase-1 and IGF-2 polymorphism in polycystic ovary syndrome].Semantic proximity Read ↗

Genomic variants in polycystic ovary syndrome.Semantic proximity Read ↗

Associations of single nucleotide polymorphisms related to insulin resistance with polycystic ovary syndrome.Semantic proximity Read ↗

Association of Paraoxonase 1 Gene Polymorphisms and Polycystic Ovarian Syndrome Susceptibility: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

Peroxisome proliferator activated receptor gamma gene variants influence susceptibility and insulin related traits in Indian women with polycystic ovary syndrome.Semantic proximity Read ↗

Role of allelic variants Gly972Arg of IRS-1 and Gly1057Asp of IRS-2 in moderate-to-severe insulin resistance of women with polycystic ovary syndrome.Semantic proximity Read ↗

A common variant in the adiponectin gene and polycystic ovary syndrome risk.Semantic proximity Read ↗

Relationship of insulin receptor substrate-1 and -2 genotypes to phenotypic features of polycystic ovary syndrome.Semantic proximity Read ↗

The role of genetic variation in peroxisome proliferator-activated receptors in the polycystic ovary syndrome (PCOS): an original case-control study followed by systematic review and meta-analysis of existing evidence.Semantic proximity Read ↗

The genetics of the polycystic ovary syndrome.Semantic proximity Read ↗

Association of PON1 gene polymorphisms with polycystic ovarian syndrome risk: a meta-analysis of case-control studies.Semantic proximity Read ↗

Paraoxonase single nucleotide variants show associations with polycystic ovary syndrome: a meta-analysis.Semantic proximity Read ↗

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