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Article

Paraoxonase single nucleotide variants show associations with polycystic ovary syndrome: a meta-analysis.

Reproductive biology and endocrinology : RB&E - 20 Nov 2020

Kunjantarachot Anthicha, Pabalan Noel, Jarjanazi Hamdi, Christofolini Denise Maria, Montagna Erik, Barbosa Caio Parente, Bianco Bianca

Abstract excerpt

BACKGROUND: Etiology of polycystic ovary syndrome (PCOS) is attributed to genetic and environmental factors. One environmental factor is oxidative stress. Paraoxonase 1 (PON1) is an antioxidant high-density lipoprotein-associated enzyme encoded by the PON1 gene. The PON1 gene has been implicated in the risk for PCOS, the influence of which appears to come from single nucleotide variants (SNVs) at multiple genetic...

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PMID: 33218342
DOI: 10.1186/s12958-020-00665-1
PMCID: PMC7678182

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