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[Combined analyses of paraoxonase-1 and IGF-2 polymorphism in polycystic ovary syndrome].

Deutsche medizinische Wochenschrift (1946) - 1 May 2009

Knebel B, Janssen O E, Hahn S, Nitzgen U, Jacob S, Haas J, Mack S, Müller-Wieland D, Kotzka J

Abstract excerpt

BACKGROUND: Apart from impaired reproductive function patients with polycystic ovary syndrome (PCOS) also have signs and symptoms belonging to the metabolic syndrome. A genetic basis for PCOS is likely as the syndrome clusters in families. Putative candidate genes are paraoxonase (PON)-1 gene and the IGF-2 INS1/VTR IGF cluster, which have been shown to be genetically linked to lipid metabolism o insulin...

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PMID: 19421925
DOI: 10.1055/s-0029-1222564

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