Article
Novel secretory vesicle proteins essential for membrane fusion display extracellular-matrix domains.
Traffic (Copenhagen, Denmark) - 1 Jul 2004
Froissard Marine, Keller Anne-Marie, Dedieu Jean-Claude, Cohen Jean
Abstract excerpt
Exocytotic mutants can be obtained in Paramecium that affect the organization of the fusion machinery, visible by electron microscopy. The site of action of the genes in the plasma membrane, cytosol or secretory compartment can easily be determined in such mutants. Functional complementation cloning of exocytotic mutants specifically affected in the secretory compartment, nd2-1 and nd169-1, reported here, and the...
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