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Article

SV40 T antigen interacts with Nbs1 to disrupt DNA replication control.

Genes & development - 1 Jun 2004

Wu Xiaohua, Avni Dror, Chiba Takuya, Yan Feng, Zhao Qiping, Lin Yafang, Heng Henry, Livingston David

Abstract excerpt

Nijmegen breakage syndrome (NBS) is characterized by radiation hypersensitivity, chromosomal instability, and predisposition to cancer. Nbs1, the NBS protein, forms a tight complex with Mre11 and Rad50, and these interactions contribute to proper double-strand break repair. The simian virus 40 (SV40) oncoprotein, large T antigen (T), also interacts with Nbs1, and T-containing cells experience chromosomal...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15175262
DOI: 10.1101/gad.1182804
PMCID: PMC420356

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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