Article
Increased caveolin-1 expression in Alzheimer's disease brain.
Neurobiology of aging - 1 Jul 2004
Gaudreault Sophie B, Dea Doris, Poirier Judes
Abstract excerpt
Increasing evidence suggests that cholesterol plays a central role in the pathophysiology of Alzheimer's disease (AD). Caveolin is a cholesterol-binding membrane protein involved in cellular cholesterol transport. We investigated the changes in the protein amount of hippocampal caveolin of autopsy-confirmed AD and aged-matched control subjects. Our results demonstrate that caveolin protein levels in the...
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