Article
Increased amount of the angiotensin-converting enzyme (ACE) mRNA originating from the ACE allele with deletion.
Human genetics - 1 Jul 2004
Suehiro Tadashi, Morita Tatsuhito, Inoue Mari, Kumon Yoshitaka, Ikeda Yukio, Hashimoto Kozo
Abstract excerpt
The insertion/deletion (I/D) polymorphism in intron 16 of the angiotensin-converting enzyme (ACE) gene is involved in the development of cardiovascular diseases. We compared the ACE mRNA expression originating from the allele with a deletion (D allele) and that from the allele with an insertion (I allele) in human white blood cells from ID heterozygotes. We identified the mRNA from the I allele by using the...
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