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Article

Electron microscopy as a quantitative method for investigating tau fibrillization.

Analytical biochemistry - 15 Jun 2004

Necula Mihaela, Kuret Jeff

Abstract excerpt

Fibrillization of tau protein is a hallmark lesion in Alzheimer's disease. To clarify the utility of electron microscopy as a quantitative assay for tau fibrillization in vitro, the interaction between synthetic tau filaments and carbon/formvar-coated grids was characterized in detail. Filament adsorption onto grids was hyperbolic when analyzed as a function of time or bulk protein concentration, with no evidence...

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PMID: 15158482
DOI: 10.1016/j.ab.2004.02.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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