Article
Effects of SU5416, a small molecule tyrosine kinase receptor inhibitor, on FLT3 expression and phosphorylation in patients with refractory acute myeloid leukemia.
Leukemia research - 1 Jul 2004
O'Farrell Anne-Marie, Yuen Helene A, Smolich Beverly, Hannah Alison L, Louie Sharianne G, Hong Weiru, Stopeck Alison T, Silverman Lewis R, Lancet Jeffrey E, Karp Judith E, Albitar Maher, Cherrington Julie M, Giles Francis J
Abstract excerpt
Acute myeloid leukemia (AML) is associated with dysregulated hematopoietic cell proliferation and increased bone marrow angiogenesis, each regulated by signaling through receptor tyrosine kinases (RTKs). SU5416 is a small molecule inhibitor of VEGF receptors, c-kit and FLT3 and therefore provides a novel opportunity to target both angiogenesis and proliferation in AML. SU5416 was assessed in a phase II...
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