Article
A phase 2 clinical study of SU5416 in patients with refractory acute myeloid leukemia.
Blood - 15 Oct 2003
Fiedler Walter, Mesters Rolf, Tinnefeld Heike, Loges Sonja, Staib Peter, Duhrsen Ulrich, Flasshove Michael, Ottmann Oliver G, Jung Wolfram, Cavalli Franco, Kuse Rolf, Thomalla Joerg, Serve Hubert, O'Farrell Anne M, Jacobs Mark, Brega Nicoletta M, Scigalla Paul, Hossfeld Dieter K, Berdel Wolfgang E
Abstract excerpt
Neoangiogenesis has been shown to play an important role in the pathogenesis of acute myeloid leukemia (AML). Autocrine and paracrine secretion of angiogenic and hematopoietic growth factors such as vascular endothelial growth factor (VEGF) and stem cell factor (SCF) in the bone marrow microenvironment may promote proliferation and survival of leukemic blasts. This concept represented the rationale for the...
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