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Article

Function of the ABC signature sequences in the human multidrug resistance protein 1.

Molecular pharmacology - 1 Jun 2004

Ren Xiao-Qin, Furukawa Tatsuhiko, Haraguchi Misako, Sumizawa Tomoyuki, Aoki Shunji, Kobayashi Motomasa, Akiyama Shin-ichi

Abstract excerpt

Human multidrug resistance protein 1 (MRP1) is a membrane ATP-binding cassette transporter that confers multidrug resistance to tumor cells by effluxing intracellular drugs in an ATP-dependent manner. The mechanisms by which transport occurs and by which ATP hydrolysis is coupled to drug transport are not fully elucidated. In particular, the function of the signature sequences in the nucleotide binding domains...

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Identifiers

PMID: 15155846
DOI: 10.1124/mol.65.6.1536

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Function of the ABC signature sequences in the human multidrug resistance protein 1.PMID 15155846Read ↗

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