Article
Analysis of the properties of the N-terminal nucleotide-binding domain of human P-glycoprotein.
Biochemistry - 9 May 2000
Booth C L, Pulaski L, Gottesman M M, Pastan I
Abstract excerpt
Human P-glycoprotein, the MDR1 gene product, requires both Mg(2+)-ATP binding and hydrolysis to function as a drug transporter; however, the mechanism(s) defining these events is not understood. In the present study, we explored the nature of Mg(2+)-ATP binding in the N-terminal nucleotide-binding domain of human P-glycoprotein and identified the minimal functional unit required for specific ATP binding....
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