There is more than one way to collect data for linkage analysis. What a study of epilepsy can tell us about linkage strategy for psychiatric disease.

doi:10.1001/archpsyc.1992.01820090073012

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Article

There is more than one way to collect data for linkage analysis. What a study of epilepsy can tell us about linkage strategy for psychiatric disease.

Archives of general psychiatry - 1 Sept 1992

Greenberg D A

Abstract excerpt

The most popular strategy for finding genes in psychiatric diseases has been to focus on large pedigrees with many affected members. While this strategy has sound advantages, it also has drawbacks that have seldom been addressed. The strategy of using smaller families also has its place in a link...

Topics

Data Collection
Epilepsies, Myoclonic
Epilepsy, Generalized
Genetic Linkage
Genetic Markers
Humans
Mental Disorders
Nuclear Family
Pedigree
Phenotype
Research Design

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