Article
Replacement of domain b of human protein disulfide isomerase-related protein with domain b' of human protein disulfide isomerase dramatically increases its chaperone activity.
FEBS letters - 21 May 2004
Horibe Tomohisa, Iguchi Daisuke, Masuoka Toshio, Gomi Mitsuhiro, Kimura Taiji, Kikuchi Masakazu
Abstract excerpt
We have reported that human protein disulfide isomerase-related protein (hPDIR) has isomerase and chaperone activities that are lower than those of the human protein disulfide isomerase (hPDI), and that the b domain of hPDIR is critical for its chaperone activity [J. Biol. Chem. 279 (2004) 4604]. To investigate the basis of the differences between hPDI and hPDIR, and to determine the functions of each hPDIR...
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