Article
Predictive factors for epidermal growth factor receptor inhibitors--the bull's-eye hits the arrow.
Cancer cell - 1 May 2004
Dancey Janet E
Abstract excerpt
Studies have shown that epidermal growth factor receptor (EGFR) signaling is important to normal development and neoplastic transformation, and that EGFR inhibition reduces cancer cell proliferation. The promising response rates of the EGFR inhibitor gefitinib in patients with chemotherapy-refractory non-small cell lung cancer (NSCLC) led to its approval for clinical use. However, there was little understanding...
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