Article
[Probability of an association between HLA- and DR-antigens in nuclear families of patients with insulin-dependent diabetes mellitus].
Problemy endokrinologii - 1 Jan 2000
Dedov I I, Domuschiev I P, Kuraeva T L, Kolokolova G P, Iakovleva D B
Abstract excerpt
Insulin dependent diabetes mellitus (IDDM) is known to associate with various antigens and alleles of the HLA-system: DR3, DR4, and DQ-determinants. However penetration of the HLA-genes, predisposing to disease, is low, suggesting a possible role of additional genes outside the HLA-system in IDDM development. Among such genes there can be a group of heavy chain Ig genes (the Gm-system). The frequency of antigens...
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