[Probability of an association between HLA- and DR-antigens in nuclear families of patients with insulin-dependent diabetes mellitus].

Article

[Probability of an association between HLA- and DR-antigens in nuclear families of patients with insulin-dependent diabetes mellitus].

Problemy endokrinologii - 1 Jan 2000

Dedov I I, Domuschiev I P, Kuraeva T L, Kolokolova G P, Iakovleva D B

Abstract excerpt

Insulin dependent diabetes mellitus (IDDM) is known to associate with various antigens and alleles of the HLA-system: DR3, DR4, and DQ-determinants. However penetration of the HLA-genes, predisposing to disease, is low, suggesting a possible role of additional genes outside the HLA-system in IDDM development. Among such genes there can be a group of heavy chain Ig genes (the Gm-system). The frequency of antigens...

Topics

Adolescent
Adult
Aged
Child
Child, Preschool
Diabetes Mellitus, Type 1
Genetic Markers
HLA Antigens
HLA-DR Antigens
Humans
Immunoglobulin Gm Allotypes

Middle Aged

Nuclear Family

Phenotype

Probability

Risk Factors

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