Article
[Alleles of HLA-DQB1 and familial aggregation of type 1 diabetes].
Medycyna wieku rozwojowego - 1 Jan 2000
Kubryn Izabela, Młynarski Wojciech, Trippenbach-Dulska Hanna, Szalecki Mieczysław, Lisowicz Lucyna, Surdej Barbara, Pilecki Olgierd, Heinrich Agnieszka, Wyka Krystyna, Perenc Małgorzata, Bodalski Jerzy
Abstract excerpt
The HLA complex, located on the short arm of chromosome 6, is the strongest genetic marker for type 1 diabetes (T1DM). In previous study we demonstrated association between genes HLA-DRB1 and HLA-DQB1 and T1DM in the Polish population. There is a strong-independent association of alleles HLA-DRB1*0401 and DQB1*302, despite population linkage disequilibrium among alleles of these genes. The aim of the current...
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