Article
[C677T and A1298C mutation of the methylenetetrahydrofolate reductase gene in unexplained recurrent spontaneous abortion].
Zhonghua fu chan ke za zhi - 1 Apr 2004
Wang Xi-peng, Lin Qi-de, Ma Zheng-wen, Zhao Ai-min
Abstract excerpt
OBJECTIVE: To investigate the association between the C677T and A1298C mutation of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene and unexplained recurrent spontaneous abortion (URSA) in Chinese population. METHODS: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the mutation of C677T and A1298C of MTHFR in 148 cases with URSA and 82 normal controls....
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