Article
Genetic makeup of the DR region in rhesus macaques: gene content, transcripts, and pseudogenes.
Journal of immunology (Baltimore, Md. : 1950) - 15 May 2004
de Groot Nanine, Doxiadis Gaby G, De Groot Natasja G, Otting Nel, Heijmans Corrine, Rouweler Annemiek J M, Bontrop Ronald E
Abstract excerpt
In the human population, five major HLA-DRB haplotypes have been identified, whereas the situation in rhesus macaques (Macaca mulatta) is radically different. At least 30 Mamu-DRB region configurations, displaying polymorphism with regard to number and combination of DRB loci present per haplotype, have been characterized. Until now, Mamu-DRB region genes have been studied mainly by genomic sequencing of...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Cell Line, Transformed
- Conserved Sequence
- Gene Expression Regulation
- Genes, MHC Class II
- Genetic Markers
- Humans
- Macaca mulatta
- Molecular Sequence Data
- Pan troglodytes
- Pedigree