Article
Humanin antagonists: mutants that interfere with dimerization inhibit neuroprotection by Humanin.
The European journal of neuroscience - 1 May 2004
Hashimoto Yuichi, Terashita Kenzo, Niikura Takako, Yamagishi Yohichi, Ishizaka Miho, Kanekura Kohsuke, Chiba Tomohiro, Yamada Marina, Kita Yoshiko, Aiso Sadakazu, Matsuoka Masaaki, Nishimoto Ikuo
Abstract excerpt
The 24-residue peptide Humanin (HN) protects neuronal cells from insults of various Alzheimer's disease (AD) genes and Abeta by forming a homodimer. We have previously shown that P3A, S7A, C8A, L9A, L12A, T13A, S14A and P19A mutations nullify the neuroprotective function of HN [Yamagishi, Y., Hashimoto, Y., Niikura, T. & Nishimoto, I. (2003) Peptides, 24, 585-595]. Here we examined whether any of these 'null'...
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