Article
Divergent roles for ferric ions in the biological activity of amidated and non-amidated gastrins.
The Journal of endocrinology - 1 May 2004
Pannequin J, Tantiongco J-P, Kovac S, Shulkes A, Baldwin G S
Abstract excerpt
Amidated forms of the peptide hormone gastrin act via the cholecystokinin-2 receptor to stimulate gastric acid secretion, whereas non-amidated forms stimulate colonic mucosal proliferation via a novel, as yet uncharacterised, receptor. Nuclear magnetic resonance (NMR) and fluorescence spectroscopic studies have revealed that glycine-extended gastrin17 bound two ferric ions, and that ferric ion binding was...
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