Article
HLA class II typing in newborns reveals a low frequency of the DRB1*04 allele and a high frequency of DRB1*11 allele in three regions of continental Italy.
Human immunology - 1 Apr 2004
Galgani Andrea, Petrone Antonio, Spoletini Marialuisa, Hodge Aaliyah, Del Buono Maria Luisa, Locatelli Mattia, Buzzetti Raffaella
Abstract excerpt
As part of a longitudinal study aimed at defining the natural history of prediabetic autoimmunity and predicting the risk of future cases of type 1 diabetes, 3607 newborns from three regions of continental Italy (Lombardia, Liguria, and Lazio) were subjected to genetic testing to determine human leukocyte antigen-DRB1 (HLA-DRB1) and -DQB1 allele and phenotype frequencies. Polymerase chain reaction and immobilized...
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