Article
Limited influence of haemoglobin variants on Plasmodium falciparum msp1 and msp2 alleles in symptomatic malaria.
Transactions of the Royal Society of Tropical Medicine and Hygiene - 1 May 2004
Mockenhaupt Frank P, Ehrhardt Stephan, Otchwemah Rowland, Eggelte Teunis A, Anemana Sylvester D, Stark Klaus, Bienzle Ulrich, Kohne Elisabeth
Abstract excerpt
Haemoglobin (Hb) S, HbC, and alpha(+)-thalassaemia confer protection from malaria. Accordingly, these traits may influence the multiplicity of infection (MOI) of Plasmodium falciparum and the presence of distinct parasite genotypes. In 840 febrile children in northern Ghana, we typed the P. falciparum merozoite surface protein genes (msp1, msp2) and examined effects of the Hb variants on MOI and parasite...
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