Role of hepatitis B virus genotypes Ba and C, core promoter and precore mutations on hepatocellular carcinoma: a case control study.

doi:10.1093/carcin/bgh172

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Article

Role of hepatitis B virus genotypes Ba and C, core promoter and precore mutations on hepatocellular carcinoma: a case control study.

Carcinogenesis - 1 Sept 2004

Yuen Man-Fung, Tanaka Yasuhito, Mizokami Masashi, Yuen John Chi-Hang, Wong Danny Ka-Ho, Yuan He-Jun, Sum Siu-Man, Chan Annie On-On, Wong Benjamin Chun-Yu, Lai Ching-Lung

Abstract excerpt

The role of hepatitis B virus (HBV) genotypes, core promoter (CP) and precore mutants on hepatocellular carcinoma (HCC) is still controversial. We aimed to determine their role on the development and clinical features of HCC. HBV genotypes and CP/precore mutations were determined in 90 HCC patients and 180 matched control patients. In the 90 HCC patients, 22 (24.4%) and 68 (75.6%) had subtype Ba and genotype C,...

Topics

Adult
Aged
Aged, 80 and over
Carcinoma, Hepatocellular
Carrier State
Case-Control Studies
Female
Genotype
Hepatitis B
Hepatitis B virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Liver Neoplasms

Male

Middle Aged

Mutation

Promoter Regions, Genetic

Risk Factors

Source

Open in PubMed

Identifiers

PMID: 15090469
DOI: 10.1093/carcin/bgh172

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15090469-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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