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Isolation and characterization of the chicken<i>bcl–2</i>gene: expression in a variety of tissues including lymphoid and neuronal organs in adult and embryo

1 Jan 1992

Abstract excerpt

The expression of human bcl-2 gene is de-regulated by t(14;18) translocation in most of follicular lymphoma. Recent studies indicated that the bcl-2 gene product has an ability to block apoptosis of hematopoietic cells. To facilitate the analysis of the role of this gene in normal development using an animal model, we have isolated and partially characterized the chicken homologue of human bcl-2 gene. The...

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PMID: 1508712
DOI: 10.1093/nar/20.16.4187

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