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Article

Ribavirin upregulates interleukin-12 receptor and induces T cell differentiation towards type 1 in chronic hepatitis C.

Journal of gastroenterology and hepatology - 1 May 2004

Shiina Masaaki, Kobayashi Koju, Satoh Hiroko, Niitsuma Hirofumi, Ueno Yoshiyuki, Shimosegawa Tooru

Abstract excerpt

BACKGROUND AND AIM: The mechanisms of ribavirin as an immune modulator have not been fully revealed, contrary to its clinical benefit in chronic hepatitis C. Recently, host immune defense, especially cytotoxic T lymphocytes and T helper cells, have been considered to be closely related to the pathophysiology of chronic viral hepatitis. The aim of the present study was to evaluate the function of ribavirin in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15086600
DOI: 10.1111/j.1440-1746.2003.03329.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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