Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Non-islet origin of pancreatic islet cell tumors.

The Journal of clinical endocrinology and metabolism - 1 Apr 2004

Vortmeyer Alexander O, Huang Steve, Lubensky Irina, Zhuang Zhengping

Abstract excerpt

The histogenesis of pancreatic islet cell tumors was investigated by morphological identification of putative precursor lesions in pancreatic tissue from patients with multiple endocrine neoplasia type 1 (MEN1), tissue microdissection, and genetic analysis. MEN1 mutation and absence of the MEN1 wild-type allele in different precursor lesions strongly suggest that pancreatic islet cell tumors are derived from the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Pluripotent Stem Cells
Share to Precancerous Conditions
Share to Proto-Oncogene Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Differentiation

Share to Germ-Line Mutation

Share to Multiple Endocrine Neoplasia Type 1

Share to Pancreas

Share to Pancreatic Neoplasms

Source

Identifiers

PMID: 15070966
DOI: 10.1210/jc.2003-031575

Genes

MEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Non-islet origin of pancreatic islet cell tumors.PMID 15070966Read ↗

Endocrine Precursor Lesions and Microadenomas of the Duodenum and Pancreas with and without MEN1: Criteria, Molecular Concepts and Clinical SignificanceSemantic proximity Read ↗

Recapitulation of Pancreatic Neuroendocrine Tumors in Human Multiple Endocrine Neoplasia Type I Syndrome via <i>Pdx1</i> -Directed Inactivation of <i>Men1</i>Semantic proximity Read ↗

Multiple Endocrine Neoplasia Type 1 (MEN1): Loss of One MEN1 Allele in Tumors and Monohormonal Endocrine Cell Clusters But Not in Islet Hyperplasia of the PancreasSemantic proximity Read ↗

Glucagon Cell Adenomatosis: A Newly Recognized Disease of the Endocrine PancreasSemantic proximity Read ↗

Aberrant Menin expression is an early event in pancreatic neuroendocrine tumorigenesis.Semantic proximity Read ↗

Microadenomatosis of the endocrine pancreas in patients with and without the multiple endocrine neoplasia type 1 syndrome.Semantic proximity Read ↗

Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development.Semantic proximity Read ↗

Histologic and Molecular Profile of Pediatric Insulinomas: Evidence of a Paternal Parent-of-Origin Effect.Semantic proximity Read ↗

Allelic deletions on chromosome 11q13 in multiple tumors from individual MEN1 patients.Semantic proximity Read ↗

Cell lineage markers in human pancreatic cancer.Semantic proximity Read ↗

Allelic deletions on chromosome 11q13 in multiple endocrine neoplasia type 1-associated and sporadic gastrinomas and pancreatic endocrine tumors.Semantic proximity Read ↗

Collision of extensive exocrine and neuroendocrine neoplasms in multiple endocrine neoplasia type 1 revealed by cytogenetic analysis of loss of heterozygosity: a case report.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.