Multiple sclerosis

doi:10.1172/jci21357

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Multiple sclerosis

15 Mar 2004

Abstract excerpt

Multiple sclerosis is a complex genetic disease associated with inflammation in the CNS white matter thought to be mediated by autoreactive T cells. Clonal expansion of B cells, their antibody products, and T cells, hallmarks of inflammation in the CNS, are found in MS. This review discusses new methods to define the molecular pathology of human disease with high-throughput examination of germline DNA haplotypes,...

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PMID: 15067307
DOI: 10.1172/jci21357

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