Article
Vertebrate development requires ARVCF and p120 catenins and their interplay with RhoA and Rac.
The Journal of cell biology - 1 Apr 2004
Fang Xiang, Ji Hong, Kim Si-Wan, Park Jae-Il, Vaught Travis G, Anastasiadis Panos Z, Ciesiolka Malgorzata, McCrea Pierre D
Abstract excerpt
Using an animal model system and depletion-rescue strategies, we have addressed the requirement and functions of armadillo repeat gene deleted in velo-cardio-facial syndrome (ARVCF) and p120 catenins in early vertebrate embryogenesis. We find that xARVCF and Xp120 are essential to development given that depletion of either results in disrupted gastrulation and axial elongation, which are specific phenotypes based...
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