Article
ARVCF depletion cooperates with Tbx1 deficiency in the development of 22q11.2DS-like phenotypes in Xenopus.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Dec 2011
Tran Hong Thi, Delvaeye Mieke, Verschuere Veerle, Descamps Emilie, Crabbe Ellen, Van Hoorebeke Luc, McCrea Pierre, Adriaens Dominique, Van Roy Frans, Vleminckx Kris
Abstract excerpt
The 22q11.2 deletion syndrome is a common dominant genetic disorder characterized by a heterozygous deletion of a cluster of genes on chromosome 22q11.2. TBX1, a transcription factor belonging to the T-box gene family, is a key player in the syndrome. However, heterozygosity of Tbx1 in mouse models does not fully recapitulate the phenotypes characteristic of the disease, which may point to the involvement of...
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