Three repeats of CCCCTCC on the pyrimidine-rich sequence in the proximal 5' flanking region are required for efficient transcriptional activity of the human endothelial nitric oxide synthase gene.

Abstract excerpt

The endothelial nitric-oxide synthase (eNOS) gene is constitutively expressed in endothelial cells, but numerous regulatory elements in the promoter region should contribute to the regulation for cell specific expression and the response to exogenous stimuli. A Sp1-binding consensus motif (-104 to -96) is essential for a core promoter activity of the human eNOS gene. In this study, we show that three repeats of...

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