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Article

Mouse models of human single gene disorders. I: Nontransgenic mice.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Jun 1992

Darling S M, Abbott C M

Abstract excerpt

Mouse models of human genetic disorders provide a valuable resource for investigating the pathogenesis of genetic disease and for testing potential therapies. The high degree of resolution of linkage mapping in the mouse allows mutant phenotypes to be mapped precisely which, combined with the accurate definition of areas of homology between the mouse and human genomes, greatly facilitates the identification of...

Topics

Animals
Chromosome Mapping
Disease Models, Animal
Genetic Diseases, Inborn
Genetic Therapy
Humans
Mice
Phenotype

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1503552
DOI: 10.1002/bies.950140602

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1503552-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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