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Article

Essential role of the NH2-terminal WD/EPF motif in the phosphorylation-activated protective function of mammalian Hsp27.

The Journal of biological chemistry - 28 May 2004

Thériault Jimmy R, Lambert Herman, Chávez-Zobel Aura T, Charest Gabriel, Lavigne Pierre, Landry Jacques

Abstract excerpt

Hsp27 is expressed at high levels after mild heat shock and contributes to making cells extremely resistant to subsequent treatments. The activity of the protein is regulated at the transcriptional level, but also by phosphorylation, which occurs rapidly during stress and is responsible for causi...

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Identifiers

PMID: 15033973
DOI: 10.1074/jbc.M402325200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15033973-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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