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Article

Selective loss of NMDA receptor NR1 subunit isoforms in Alzheimer's disease

10 Mar 2004

Abstract excerpt

Previous work had shown that the ratio of NMDA receptor NR1 subunit mRNA transcripts containing an N-terminal splice cassette to those that do not is markedly lower in regions of the Alzheimer's disease (AD) brain that are susceptible to pathological damage, compared with spared regions in the same cases or homotropic regions in controls. To elucidate the origins of this difference in proportionate expression, we...

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PMID: 15030408
DOI: 10.1111/j.1471-4159.2003.02330.x

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