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BRCA1 and BRCA2 germline mutation spectrum and frequencies in Belgian breast/ovarian cancer families

24 Feb 2004

Abstract excerpt

Worldwide variation in the distribution of BRCA1 and BRCA2 mutations is well recognised, and for the Belgian population no comprehensive studies about BRCA1/2 mutation spectra or frequencies have been published. We screened the complete coding region of both genes in 451 individuals from 349 Belgian families referred to a family cancer clinic and identified 49 families with a BRCA1 and 26 families with a BRCA2...

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PMID: 15026808
DOI: 10.1038/sj.bjc.6601656

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