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Article

High frequency of BRCA1/2 germline mutations in 42 Belgian families with a small number of symptomatic subjects.

Journal of medical genetics - 1 Apr 1999

Goelen G, Teugels E, Bonduelle M, Neyns B, De Grève J

Abstract excerpt

AIM: The initial risk assessments for BRCA1/2 mutation carriers and estimates of carrier frequencies were based on extended pedigrees with a large number of symptomatic subjects. When counselling based on BRCA gene mutation analysis was initiated, we faced requests for counselling mostly from members of small families with only two or three affected members. We report on the likelihood of finding a BRCA mutation...

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Source

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Identifiers

PMID: 10227398
PMCID: PMC1734354

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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