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Human Mesenchymal Stem Cells Form Purkinje Fibers in Fetal Sheep Heart

16 Mar 2004

Abstract excerpt

BACKGROUND: We have investigated the usefulness of a model of cardiac development in a large mammal, sheep, for studies of engraftment of human stem cells in the heart. METHODS AND RESULTS: Adult and fetal human mesenchymal stem cells were injected intraperitoneally into sheep fetuses in utero. Hearts at late fetal development were analyzed for engraftment of human cells. The majority of the engrafted cells of...

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PMID: 15023887
DOI: 10.1161/01.cir.0000124222.16321.26

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