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Article

Weakened expression of 'e' owing to concomitant occurrence of Cys16 and Val245 (VS antigen).

Vox sanguinis - 1 Feb 2004

Rodrigues A, Rios M, Costa F F, Saad S T O, Pellegrino J, Castilho L

Abstract excerpt

BACKGROUND AND OBJECTIVES: The 48 G>C transversion in exon 1 of the RHCE gene leads to Trp16Cys, usually present in the conventional RHCE Ce, while Trp16 is associated with RHCE ce. The presence of Cys16 in RHCE ce is associated with the R(0) (Dce) haplotype in Africans, leading to a weak 'e' antigen expression on red blood cells (RBCs). VS is a common red cell antigen in individuals of African descent and...

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Source

Identifiers

PMID: 15023184
DOI: 10.1111/j.0042-9007.2004.00399.x

Genes

RHCE
SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Weakened expression of 'e' owing to concomitant occurrence of Cys16 and Val245 (VS antigen).PMID 15023184Read ↗

Molecular background of VS and weak C expression in blacks.Semantic proximity Read ↗

Heterogeneous molecular background of the weak C, VS+, hr B-, Hr B- phenotype in black persons.Semantic proximity Read ↗

The low prevalence Rh antigen Be(a) (Rh36) is associated with RHCE*ce 662C>G in exon 5, which is predicted to encode Rhce 221Arg.Semantic proximity Read ↗

RHCE*cE734C allele encodes an altered c antigen and a suppressed E antigen not detected with standard reagents.Semantic proximity Read ↗

A novel RHCE*ce 48C, 733G allele with Nucleotide 941C in Exon 7 encodes an altered red blood cell e antigen.Semantic proximity Read ↗

A novel RHCE*Ce710A allele (p.237Asp) in a Japanese patient with weak expression of C and no detectable e.Semantic proximity Read ↗

A novel RHCE*02 allele, containing the single-nucleotide change c.460A>G, encodes weakened expression of C and e antigens.Semantic proximity Read ↗

Analysis of RhCE variants among 806 individuals in France: considerations for transfusion safety, with emphasis on patients with sickle cell disease.Semantic proximity Read ↗

RHCE*ceAG (254C>G, Ala85Gly) is prevalent in blacks, encodes a partial ce-phenotype, and is associated with discordant RHD zygosity.Semantic proximity Read ↗

RHCE*01 48G>C, 366del allele with silenced RHCE*ce expression.Semantic proximity Read ↗

Variant genotypes associated with reduced expression of RhCE antigens among Brazilian blood donors.Semantic proximity Read ↗

A novel RHCE*cE allele identified in a Chinese individual, encodes weakened expression of c and E antigens.Semantic proximity Read ↗

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