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Article

A cellular UDP-glucose deficiency causes overexpression of glucose/oxygen-regulated proteins independent of the endoplasmic reticulum stress elements.

The Journal of biological chemistry - 21 May 2004

Flores-Diaz Marietta, Higuita Juan-Carlos, Florin Inger, Okada Tetsuya, Pollesello Piero, Bergman Tomas, Thelestam Monica, Mori Kazutoshi, Alape-Giron Alberto

Abstract excerpt

A low level of UDP-Glc occurs in cells exposed to hypoxia or glucose starvation. This work reveals that a 65% reduction in the cellular UDP-Glc level causes up-regulation of the mitochondrial chaperone GRP75 and the endoplasmic reticulum (ER) resident chaperones GRP58, ERp72, GRP78, GRP94, GRP170...

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Source

Identifiers

PMID: 15020602
DOI: 10.1074/jbc.M312791200

Genes

ATF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15020602-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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